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ClinicalTrials.gov records show ongoing or recently updated trial activity, reinforcing that the compound remains under investigation

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In an experimental model of diabetic nephropathy, rubositoline has been shown to normalize glomerular hyperfiltration by inhibiting PKC-, reduce urinary albumin excretion, maintain renal function, and mitigate mesangial dilation, glomerular sclerosis, and tubulointerstitial fibrosis