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Our clinic does this through biomarker testing, individualized protocols, and ongoing physician supervision

10.1007/s11655-017-2758-4 116 RahimiR.NikfarS.LarijaniB.AbdollahiM

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(1988) characterized IGFBP binding determinants in the IGF-1 molecule, providing the structural basis for the R3 substitution that became the foundation of the LR3 design (PMID 3356790)