As more exatecan-based ADCs enter clinical trials, oncologists will face increasingly complex treatment sequencing decisions, and developers may need to explore alternative payloads to preserve efficacy across treatment lines
Avoiding chronic sleep debt, late-day caffeine, and excessive alcohol further removes common suppressors of longevity & aging-related signaling
Liu Y, Zhang S, Liu K, Hu X, Gu X
Plasma histamine was shown to reduce after insulin administration in diabetic rats (ref)
Medications: Sodium-glucose cotransporter-2 inhibitors 12 , DHEA 13 , dopamine agonists 14 and verapamil 15 can increase IGF-1 levels, while clomiphene citrate 16 , atorvastatin 17 and long-term somatostatin analogues can reduce IGF-1 18