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2.2 Immune-regulatory mechanisms in acute pancreatitis 2.2.1 Inflammatory pathways in acute pancreatitis AP triggers an inflammatory response through the activation of multiple signaling pathways, primarily driven by the release of key cytokines such as TNF-, IL-6, and IL-1 ( 2.2.2 Macrophage polarization and pyroptosis in acute pancreatitis Macrophages are classified into two main types based on their polarization: pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages ( ELAV1 gene knockout mice to develop an AP model, revealing that ELAV1 upregulates TRAF6 expression, which enhances TLR signaling and promotes M1 macrophage polarization, thereby worsening the course of AP

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Comparison of the Effects of Vaginal Royal Jelly and Vaginal Estrogen on Quality of Life, Sexual and Urinary Function in Postmenopausal Women