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In the natural aging + FOXO4-DRI group, mice received intraperitoneal injections of FOXO4-DRI (5 mg/kg, MCE, HY-P4157) every 2 days during the same period, followed by tissue collection

Ethanol suppresses Akt phosphorylation and mTOR activity, thereby enhancing susceptibility to apoptosis and inhibiting autophagy-mediated clearance of damaged proteins [41,48]

Taken together, these findings suggest that TB-500 may promote a collagen network that is both better organized and mechanically more robust, indicating its potential to accelerate ligament recovery in laboratory settings

Role of altered metabolism of triglyceride-rich lipoprotein particles in the development of vascular dysfunction in systemic lupus erythematosus