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63 However, the fact that different patients present with SS at differing drug dosages and/or combinations suggests that there may also be underlying genetic and pharmacodynamic factors that modulate susceptibility

These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

Himmelseher S, Pfenninger E, Kochs E, Auchter M

Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I

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