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Integrating NO donors with other treatments enhances therapeutic efficacy

by Dennis Crouch Since late 2022, the extraordinary demand for glucagon-like peptide-1 receptor agonists (GLP-1s) like Eli Lilly's tirzepatide (marketed as Mounjaro for diabetes and Zepbound for weight loss) has created a persistent nationwide shortage

But that day, if it ever comes, is likely many years away

Clinical trials leading to FDA approval tested this regimen, and dose escalation follows a four-week interval schedule to allow steady-state achievement before advancing to the next level

Della Ragione, F., Vacca, M., Fioriniello, S., Pepe, G