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In contrast, the mean relative risk reduction in studies involving individuals with T2D, where weight loss was between 2% and 5%, was 15%, as seen in the aforementioned trials (48, 57, 59, 71)

The effects of GLP-1s appear to be more subtle

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115 Cerebral insulin resistance may arise from the downregulation of insulin transport across the blood-brain barrier secondary to chronic peripheral hyperinsulinemia and systemic insulin resistance 116 as well as from the loss of neuronal membrane insulin receptors induced by soluble amyloid-beta (A) oligomers