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The classical somatomedin hypothesis (Salmon and Daughaday, 1957, foundational sulfation factor research) assumed all peripheral IGF-1 came from this hepatic source

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Desempea un papel fundamental en numerosas reacciones metablicas y bioqumicas tales como la sntesis y reparacin del ADN, la sntesis de protenas, la sntesis de prostaglandinas, el transporte de aminocidos y la activacin de enzimas