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Overall, extensive experimental evidence demonstrates that estrogen replacement therapies improve skin quality (thickness, elasticity, hydration), accelerate healing, and protect against the development of chronic wounds in aged humans and estrogen-deprived animal models (Kanda and Watanabe, 2003

It is commonly referenced in in vitro research examining peptide stability, molecular signaling behavior, and gastrointestinal pathway investigation

This is a dissociation between what happens in the dermis (good) and what happens in the epidermis (potentially concerning for already-thin post-menopausal skin)

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Nature 454 , 345349 (2008)