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Although dietary calcium restriction was previously thought to lower urine calcium and calcium-containing stone risk, evidence from multiple large observational studies and a randomized controlled trial has shown that calcium restriction does not prevent stone formation (Friedlander 2015)

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The results were notable: participants receiving the highest dose (12 mg) achieved a mean body weight reduction of approximately 24% , which is among the largest reductions observed in any pharmacological weight-loss trial to date

This pathway included PLC-dependent activation through G i coupling, ultimately leading to release of Ca 2+ from the endoplasmic reticulum via IP 3 receptors (Fig