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In people with HF, this is accompanied by a metabolic shift toward water and energy conservation [33], resembling estivation, a physiological adaptation observed in animals during prolonged nutrient and water scarcity [34]

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Nevertheless, its antidepressant effects have been demonstrated in mice via abdominal injection, suggesting that its pharmacokinetic propertiesparticularly regarding absorption and brain distributiondeserve further investigation (Zhou Y

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