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Furthermore, a recent finding demonstrated that -synuclein released from injured dopaminergic neurons triggers activation of NF-B and release of pro-inflammatory cytokines with further aggravation of dopaminergic neurons in a positive-loop fashion (Dolatshahi et al

If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency

6 Typically, titration (staggered dose increases) was slower compared to clinical trials

One RCT showed skin brightening in 37.5% of subjects after 12 IV sessions

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