A distinguishing feature of Retatrutide is its stimulation of the glucagon receptor, which is associated with energy expenditure and fat-mobilisation processes
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One very small study found that people who used semaglutide had lower B12 levels, but these patients also had bariatric surgery prior to using semaglutideso its hard to say if using semaglutide would lead to a B12 deficiency, requiring additional B12
It's also important that folate intake doesn't mask a B12 deficiency, which requires professional oversight to prevent nervous system damage
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