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VEGF upregulation, for example, is also associated with pathological angiogenesis

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Lifestyle interventions, mostly aiming at diet and physical activity improvement, represent the foundation of obesity treatment, yet an escalation to pharmacological and/or surgical interventions is often needed 5

Salviolone, a bisnorditerpene compound derived from Salvia miltiorrhiza and Salvia paramiltiorrhiza, has been shown to have inhibitory effects on melanoma cells by inhibiting matrix metalloproteinase 2 activity and the STAT3 pathway [41]