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Clemente-Surez VJ, Beltrn-Velasco AI, Redondo-Flrez L, Martn-Rodrguez A, Tornero-Aguilera JF (2023) Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review

The compound has not yet received regulatory approval and remains under evaluation in Phase 3 studies, which aim to determine its long-term safety profile, durability of weight reduction, and extended metabolic effects

Use of treatment was defined as the observation from the first filled prescription onwards

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These findings suggest a possible modulatory effect on HPO signaling, potentially mediated by anti-inflammatory pathways, although causality and long-term reproductive implications remain uncertain