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216 Furthermore, a randomized, double-blind, placebo-controlled trial in 65 hemodialysis patients reported that taking 1,200 mg, but not 600 mg, of CoQ10 daily for four months decreased oxidative stress (as indicated by a decrease in F2-isoprostanes)
These ulcers exemplify the combined effect of oxidative stress and chronic inflammation, where inflammation and ROS together create a feedback loop that exacerbates immune dysfunction and worsens neuropathy, complicating patient care [42,46]