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Cases of pancreatitis (inflammation of the pancreas), thyroid cancer, and diabetic retinopathy have been reported
In sepsis caused by Gram-negative bacteria, overactivation of GLP-1 within the first 24 h has been associated with increased mortality risk, suggesting a complex and potentially adaptive regulatory role (Brakenridge et al., 2019)
Studies have explored conjugating ferroptosis inducers, such as RSL3 prodrugs or GPX4-targeting siRNA, to HER2 antibodies or their fragments (e.g., scFv), to construct siRNAantibody fusion nanosystems capable of recognizing and binding to the surface of HER2-positive cells, thereby triggering endocytosis and targeted intracellular drug release
Moreover, Pyy knockout mice exhibit hyperinsulinemia in both fasted and fed states compared with wild-type mice 22