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They result from a combination of factors such as decreased collagen and elastin production, loss of hydration, and cumulative damage from environmental factors like UV exposure

If they were persistent or severe, the parents were offered the option to discontinue the study

The addition of ionomycin to iRPMI alone induced a rapid and significant increase of PS exposure after only 1 h incubation (T 1h =0.1% in DMSO vs