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10.1161/CIR.0000000000000973 48

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when cardiac cytoplasmic Na + and Ca 2+ concentrations and mitochondrial Ca 2+ were measured fluorometrically in isolated ventricular myocytes from rabbits and rats, the results evidenced that empagliflozin directly inhibited NHE flux, caused by a reduction in cytoplasmic Na+ and Ca 2+ concentrations and an increase in mitochondrial Ca 2 [118]

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