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Formulation, pharmacy quality, dosing, and individual response can differ from brand products

Further expanding this paradigm, triple agonists such as retatrutide (GLP-1/GIP/glucagon) are in Phase III trials, with Phase II data reporting weight reductions exceeding 24% and favorable tolerability [79,80,81,82]

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Why Post-Approval Data Is the Most Commercially Valuable and Most Legally Vulnerable New Matter Post-approval discoveries new dosing regimens validated in Phase IV trials, new patient sub-populations identified through real-world evidence, device improvements incorporated into combination product submissions generate some of the highest-value secondary patents in pharmaceutical portfolios