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LD: Data curation, Investigation, Methodology, Writing original draft

[DOI] [PubMed] [Google Scholar] Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, Shannon RP

Despite their diverse pharmacological properties, these drugs converge on shared neurotoxic pathways, including oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation

Research has indicated that the -KG-consuming protein Tet3 (the primary -KG-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and then into 5-formyl- and 5-carboxy-dC) reroutes mitochondrial GDH, which converts glutamate into -KG in an NAD + -dependent manner, to the nucleus, indicating the onsite production of -KG

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