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Signalling activates PLC- DAG + IP3 intracellular Ca + PKC (via Gq) plus Gs-cAMP-PKA, with a balanced profile neither Gs- nor -arrestin-biased in recent cryo-EM and BRET studies (2020-2023)

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It is more difficult to predict the solubility of polar molecular substances than to predict the solubility of ionic compounds and nonpolar molecular substances

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This suggests that tirzepatide produced greater average weight loss than semaglutide in that head-to-head obesity trial