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CR-fed females showed upregulation of pathways including Lysine degradation, and Valine, leucine, and isoleucine degradation. Interestingly, DL-fed females had no significantly upregulated pathways, and indeed CR-fed females had upregulation of Valine, leucine, and isoleucine biosynthesis, while DL-fed females had downregulation of this same pathway

Tirzepatide activates both GLP-1 and GIP receptors and may produce slightly greater weight loss in some patients

This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences

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