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This begins with assessing the methodology used, given the variability across approaches

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However, transplantation of MPO -/- macrophages into Ldlr -/- mice, also markedly increased atherosclerosis, and this was confirmed in MPO -/- / Ldlr -/- double knockout mice compared to MPO +/+ / Ldlr -/- controls (289)

Among the 8 identified metabolites, the levels of L-acetylcarnitine, L-carnitine, ribonic acid, and glucaric acid tended to increase from stage 1 and became significantly higher in stage 3 when compared to controls (Fig