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However, emerging evidence suggests that genetic variants in GLP1R, GIPR, and FTO pathways may influence individual medication efficacy and side-effect tolerance

Mingorance et al., 2011)

In situations where use of a medication is necessary and alternatives are not available, there can be shared decision making with the patient to consider a drug challenge test in unique scenarios [138]

doi: 10.1371/journal.pone.0070196 99 LiuYGuerrero-JuarezCFXiaoFShettigarNURamosRKuanCHet al

Pharmaceuticals (Basel) 17(12):1655 Picoli CC, Tsibulnikov S, Ho M, Demambro V, Feng T, Eltahir M, Le PT, Chlebek C, Rosen CJ, Ryzhov S, Li Z (2025) Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice