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The reduced IGFBP affinity results in a dramatically extended half-life compared to native IGF-1, making IGF-1 LR3 valuable for laboratory research involving: Extended IGF-1 receptor activation studies Prolonged growth factor signaling pathway research IGFBP interaction and modulation studies Comparative studies with native IGF-1 For Canadian researchers studying growth factor pathways, IGF-1 LR3 provides a tool for understanding sustained receptor activation without the rapid clearance seen with native IGF-1

Bull World Health Organ 2004 Nov

Furthermore, changes in the number of CTC after treatment were more strongly associated with survival than were changes in PSA at 4, 8 and 12 weeks post treatment (de Bono et al, 2008