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GLP-1 is one of the gut hormones that profoundly affects glucose regulation by promoting post-prandial insulin secretion, and GLP-1 based drugs are approved for the treatment of T2D (74)

Early preclinical studies suggested GLP-1 receptor expression in thyroid C cells, forming the basis for rodent findings of C-cell hyperplasia and medullary thyroid carcinoma under chronic GLP-1RA exposure [47,48]

Want A, Thomas OR, Kara B, Liddell J, Hewitt CJ

doi: 10.1111/jth.14234 Summary Keywords trimethylamine N-oxide, atherosclerosis, cardiovascular disease, inflammation mechanism, clinical prognostic stratification, therapy Citation Yang S, Li X, Yang F, Zhao R, Pan X, Liang J, Tian L, Li X, Liu L, Xing Y and Wu M (2019) Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target