Our Take You're 90 minutes into a long ride and your stomach is already talking back
During physiological stimulation by ACh or CCK, repetitive Ca 2+ spikes in the apical cytosol trigger both zymogen granule exocytosis and mitochondrial activation, ensuring that ATP generation is tightly coupled to the energetic cost of enzyme secretion ( 2+ signaling with ATP supply
Embo J 1(3):339343 Meyer Y, Belin C, Delorme-Hinoux V, Reichheld JP, Riondet C (2012) Thioredoxin and glutaredoxin systems in plants: molecular mechanisms, crosstalks, and functional significance
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When appetite is chemically suppressed and eating windows are compressed, patients may consume too little volume, leading to inadequate fluid intake and electrolyte imbalances