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In addition to the reported GI blood loss that can play a role in iron deficiency seen in endurance athletes, such as marathon and distance runners, I think that excess sweating may also play a role in why iron deficiency is so common in these types of athletes

Propionyl-CoA enters the TCA cycle after it is carboxylated by propionyl-CoA carboxylase and then metabolized to succinyl-CoA, thereby (re-) filling the (deficient) C4 TCA cycle intermediate pool (reviewed in Brunengraber and Roe, 2010

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Lean Mass Preservation Strategy GLP-1-induced weight loss includes reductions in both fat and lean body mass