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International Journal of Molecular Sciences, 19(7), 1987

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The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis

Irwin RE, Cook D, Richardson LL, Manson JS, Gardner DR

Splitting 0.5mg into two 0.25mg administrations 12 hours apart reduces peak plasma concentration by approximately 40%, lowering nausea incidence without reducing cumulative 24-hour receptor occupancy