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Managing Oxidative Stress Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules that can damage cells) and the antioxidants meant to neutralize them

Vitamin B12 is an essential water-soluble vitamin that plays roles in DNA production, red blood cells, and nerve cells

This process triggers a potent inflammatory response, characterized by the upregulation of pro-inflammatory cytokinesincluding IL-1 and interferon- (IFN-)and the concomitant downregulation of tight junction proteins, thereby compromising mucosal barrier integrity 76

It binds copper ions and has been studied for its role in supporting wound healing, collagen and elastin production, antioxidant defense, and the appearance of skin elasticity

Another important oxidant responsive cis element regulating GCL genes is the AP-1 binding site (also called the TRE element)