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Four potentially lethal toxins have been isolated from the Gila monster's venom, which cause hemorrhage in internal organs and exophthalmos (bulging of the eyes), [38] and helothermine, which causes lethargy, partial paralysis of the limbs, and hypothermia in rats

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[DOI] [PubMed] [Google Scholar] 139.Aziz T, Hussain N, Hameed Z, Lin L

The structural similarity between IGF1R and the insulin receptor means LR3 can be used to probe questions about cross-receptor signaling and the metabolic effects of IGF axis activation