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Furthermore, there was potential selection biasinclusion criteria required patients to exhibit at least two specific symptoms (e.g., muscle cramping, hypotension), which may not represent the wider hemodialysis population, thereby limiting generalizability

Specific examples can be seen in Figure 24b and 25b

Another significant milestone was the use of drug combinations in prescriptions during the 1950s, despite limited knowledge about the mechanisms involved

89 Whirl-CarrilloM.HuddartR.GongL.SangkuhlK.ThornC

According to Novo Nordisk, the oral formulation has also demonstrated # , and the company states it is now approved in the , , , ,