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By engaging GLP-1 Rs across the gut-brain axis, these agents potentiate physiological satiety signals, slowing gastric emptying, suppressing hunger cues, and diminishing the hedonic appeal of calorie-dense foods

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TB-500 is a synthetic version of a fragment of Thymosin Beta-4, a protein present at high concentrations throughout human tissue that plays a central role in cell migration, angiogenesis, and the regulation of inflammation

highlight, in both groups, a general clinical improvement, with positive effects on pain and depressive symptoms, but neither induced a significant improvement in anxiety

10.1002/prot.25004