AOM-treated mice show discontinuous staining for SMI71, while mice pretreated with neutralizing antibodies against TGF show continuous staining similar to vehicle-treated mice (Figure 7d)
doi: 10.3389/fphar.2025.1620870 Received 06 May 2025 Accepted 25 June 2025 Published 11 July 2025 Volume 16 - 2025 Edited by Kefang Sun, Rochester General Hospital, United States Reviewed by Irena Mladenova, Trakia University, Bulgaria Chengu Niu, Rochester Regional Health, United States Hsi-Chang Shih, Johns Hopkins University, United States Updates Copyright 2025 Yuan, Yang, Han, Yang and Tu

Comparison CompoundClassPathway / targetResearch focusFormat 5-Amino-1MQSmall moleculeNNMT inhibitionNAD / SAM metabolismVial 5-Amino-1MQ CapsulesSmall moleculeNNMT inhibitionNAD / SAM metabolismCapsules SLU-PP-332Small moleculePan-ERR agonismMitochondrial gene expressionVial SLU-PP-332 CapsulesSmall moleculePan-ERR agonismMitochondrial gene expressionCapsules Tesofensine CapsulesSmall moleculeMonoamine reuptakeCNS / monoaminergic signallingCapsules Enclomiphene CapsulesSmall moleculeEstrogen receptor (SERM)HPG-axis signallingCapsules AICARSmall moleculeAMPK activationCellular energy sensingVial AOD-9604Peptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingVial AOD-9604 CapsulesPeptide fragmenthGH fragment (176-191) signallingLipolytic-pathway signallingCapsules GLP-3 (Reta)PeptideIncretin receptorMetabolic signalling researchVial Every compound in this category is supplied as Research Use Only material with: Peer-reviewed literature and mechanism background underpinning this category are maintained in the linked research articles below

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J Nat Sci