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Importantly, these cardiovascular benefits were demonstrated specifically in the LEADER population: patients with type 2 diabetes at high cardiovascular risk

The pathways below are being leveraged along with GLP-1s in the clinical development of products that have dual and sometimes triple agonistic (or activation) effects

CrossRef Ferroptosis modulation by METTL14 in cancers: From molecular insights to therapeutic strategies Boran Huang, Chenglin Zhu, Xinyu Zhang, Qi Zhang, Honggang Wang Cellular Signalling .2026

As the disease advances, ferroptosis-induced release of damage-associated molecular patterns (DAMPs), exosomal transmission, and immune evasion mechanisms further amplify neuroinflammation and cell damage, establishing a cascade of intercellular pathological propagation that accelerates neurodegeneration

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