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Anytime you increase your glutathione stores, the demand for enzymes that recycle and use it also increases

In contrast to the G-site that binds GSH across GST classes, the H-sites that bind various substrates have distinct variations in amino acid sequence and structural conformation [90]

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BMC Gastroenterol 17:96 Kovacs-Nolan J, Rupa P, Matsui T, Tanaka M, Konishi T, Sauchi Y, Sato K, Ono S, Mine Y (2014) In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation