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The interaction is so dangerous that the FDA has included a boxed warning, the most serious type of alert, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Other Drug Classes That Cause Drowsiness Any CNS depressant, listed in the above table, can be problematic when used with alprazolam, because they increase the risk of drowsiness, dizziness, being off-balance, and difficulty concentrating

Shim JA, Son YA, Park JM, Kim MK

Aside from the long-term health effects we cant know, my main hesitation stemmed from popular health culture

When to Discuss Side Effects with Your Provider and Dosing Adjustments Mild to moderate fatigue that improves within 24 weeks is common and generally does not require dose reduction

Lennicke, C