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Hormone pellet therapy involves the insertion of tiny, custom-compounded pellets typically made from bioidentical estrogen or testosterone just beneath the skin, usually in the hip or buttock area

refers to discoloration on different parts of the body

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The protocol (Supplementary Appendix A) was developed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines [6] and has been published on PROSPERO (ID: CRD420251051447)

Glucagon increases energy expenditure by promoting thermogenesis in brown fat tissue