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It is concluded that the extent of dGSH adduct, representing that of reactive metabolites, formed by rat liver microsomes correlate well with hepatotoxicity profile of a compound

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Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72