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Study design: Treat-to-target, randomized, double-blind, active comparator-controlled, event-driven cardiovascular outcomes trial assessing the noninferiority of once-daily Tresiba U-100 (n=3818) and once-daily insulin glargine U-100 (n=3819) in terms of the incidence of cardiovascular events

Casein reactivity, or dairy protein intolerance, occurs when the immune system mistakenly recognizes casein protein as a harmful substance and mounts an allergic response

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Summary: Low blood sugar risk with retatrutide is theoretically lower than with sulphonylureas or insulin due to its glucose-dependent mechanism, but the risk increases when retatrutide is combined with other glucose-lowering therapies

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