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Applied Clinical Trials (December 2025)

Novo Nordisk studied Wegovy against placebo in addition to standard of care for prevention of major adverse cardiac events in 17,604 adults with heart disease and obesity or who were overweight, but who didnt have diabetes

PubMed Central , Accessed 23 Apr

For example, using 7 different drug classes of antidiabetics as a comparator group can also be problematic as each drug class can be a proxy for different levels of diabetes severity which propensity score matching alone might not be able to fully adjust for