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To address heterogeneity, the population, intervention, comparison, outcome, and study design (PICOS) framework was utilized in setting up a search strategy (Table 1)

In our sample, there are significant differences between males and females, as well ( p = 0.018)

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A large electronic health record cohort study found that patients who used phentermine beyond three months did not show increased cardiovascular adverse events, including no elevated risk of heart attack, stroke, or death over three years of follow-up

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