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Some protocols suggest localized administration for specific injury sites

Pain near the injection site can occur if a person inserts the needle at an unsuitable angle or if the needle moves slightly during the injection

Wolffenbuttel BHR et al

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Abstract Aim The aim of this study was to evaluate oxidative stress from glutathione depletion in critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid (PyroGlu) in the urine (indirectly) and through its serum level (directly)