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BMJ Open 12 , e057142 (2022)

They function as signaling molecules to stimulate the bodys own production of growth hormone, unlike anabolic steroids which are synthetic derivatives of testosterone

Therefore, cortisol may prevent rather than cause oxidative stress and may activate antioxidant defences via genomic pathways in addition to influencing other systems that regulate the formation of pro-oxidants like ROS (65)

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However, while vitamin B12 supplements may help those with neurological function concerns or deficiencies, the evidence isnt strong enough to support its use as a standalone treatment for depression