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IGF-1 increases the potency of kainate-dependent currents in cerebellar granule neurons and modulates Ca 2+ , Cl , and K + channels by PI3K-dependent pathway, but not MAPK dependent pathway [73, 79]
The water-down-the-wall technique, the gentle swirl, the 28-day storage window, the temperature requirements, all of these principles apply to virtually every lyophilized peptide
[4] Structural Features MT-2 is described as a heptapeptide, consisting of 7 amino acids
The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise
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