Knop: Back in 2009, in my effort to better understand how the gut hormone glucagon-like peptide 1 (GLP-1) is secreted, I read TGR5-mediated bile acid sensing controls glucose homeostasis (Thomas, et al.), which described how bile acids may stimulate the secretion of this glucose-lowering and satiety-promoting hormone
Sophie Dix (BSc, PhD) Published: 17 June 2025 | Updated: 7 May 2026 Updated: 7 May 2026 Reading time: 8 minutes Quick navigation: Article Summary: What is titration
Some people may experience slight discomfort, such as a cool sensation at the injection site or mild nausea, which typically resolves after the session
This portfolio reflects Lillys strategy of pursuing multiple complementary approaches to metabolic disease: Tirzepatide : Dual GIP/GLP-1 agonist (approved, injectable) Retatrutide : Triple GIP/GLP-1/glucagon agonist (Phase 3, injectable) Orforglipron : Oral GLP-1R agonist (Phase 3, oral) If retatrutide is approved, it could be positioned as a more potent option for patients requiring greater weight loss or those with MASLD, while tirzepatide and orforglipron serve other patient segments
86 In 6-OHDA/LPS-challenged rodents, the apomorphine circling behavior was alleviated by exenatide in a dose-dependent manner
