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It is unclear whether this observation was due to the effects of time-restricted feeding (ie, intermittent fasting), a lower overall caloric intake with once-daily feeding (ie, caloric restriction), or whether pre-existing health conditions in the dogs may have affected how frequently they were fed

A steady reduction in astrocytic glutamate transporters, reduced capacity to buffer and disperse K + , and an overall decrease in their ability to sense synaptic activity (partly due to reduced density of ionotropic receptors) was also observed in aged mice (2024-months-old), disrupting long-term potentiation of synapses in the hippocampus (Lalo et al., 2011

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Combination with suberoylanilide hydroxamic acid (SAHA) can effectively control the growth of GBM xenografts