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Construct Validity The construct validity of disease models is determined by whether the etiology and pathogenesis leading to the disorder in the model correspond to those of the human disease

The authors also reported a significant correlation between eryptosis and other biological markers of inflammation and oxidative stress [390]

Mechanistically, metformin may activate Nrf2 through multiple pathways, including AMPK activation, inhibition of GSK-3mediated Nrf2 degradation, and modulation of intracellular redox homeostasis, all of which facilitate Nrf2 nuclear translocation and subsequent induction of downstream antioxidant genes 48,49

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy